Trophoblastic Neoplasms Adults : 15-30mg peroral (PO)/ intramuscular (IM) once daily, given for 5 days.
Acute Lymphocyic Leukemia Adults & children : 3.3mg/m2 IV daily for 4-6 weeks or followed by maintenance therapy with 20-30mg/m2/PO/IM given twice weekly.
Breast Cancer Adults & Children : 40-60mg/m2 IV given on day 1 of every 21-28 days along with cyclophosphamide & fluorouracil.
Head & Neck Cancer Adults & Children : 40mg/m2 IV on days 1 & 15 of every 21 days alone or with bleomycin & cisplatin.
Cutaneous T-cell Lymphoma Adults : 50mg IM once weekly or 25mg twice weekly.
Lung Cancer : Methotrexate 20mg/m2 IV as a single dose along with cisplatin, doxorubicin & cyclophosphamide repeated every 28 days.
Dosage Adjustment :
Renal Impairment : Required.
Hepatic Impairment : Required.