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Oxaliplatin Injection 50mg / 25ml
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Oxaliplatin Injection 100mg / 50ml
As adjuvant treatment of stage III colon cancer
In combination with infusional 5-FU/LV, is indicated for the treatment of advanced carcinoma of the colon or rectum.
The recommended dose of oxaliplatin injection as single agent is 130/mg/m², given intravenously over at least 2 hours, every three-four weeks. In case of combination the recommended dose schedule given every two weeks is as follows :
Day 1 : Oxaliplatin 85 mg/m² IV infusion in 250-500 ml of Dextrose 5% and Leucovorin 200 mg/m² IV infusion in Dextrose 5% both given over 120 minutes.
Day 2 : Leucovorin 200 mg/m² IV infusion over 120 minutes, followed by Fluorouracil 400 mg/m² IV bolus given over 2-4 minutes, followed by Fluorouracil 600 mg/m² IV infusion in 500 ml Dextrose 5% (recommended) as a 22-hour continuous infusion.
Renal Impairment : Required in severe impairment.
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